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Astellas Pharma Senior Research Associate, Bioanalytics in South San Francisco, California

Sr. Research Associate, Bioanalytics

Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

About Astellas Gene Therapies

Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.astellasgenetherapies.com.

The Role

The primary purpose of the Senior Research Associate in Bioanalytics is to analyze tissue samples taken from our nonclinical research studies dosed with gene therapy candidates. The Senior Research Associate will process tissues for critical endpoints, run analysis on the appropriate instrument, and analyze data outcomes. In addition, the Senior Research Associate will QC data, optimize protocols, and assist in new assay development.

Responsibilities

  • Extract protein, DNA and/or RNA from necropsied animal tissue

  • Run ddPCR, qPCR, ELISA, Western Blot etc analysis on tissue extracts

  • Cell culture, Neutralizing antibody assays and total antibody assays

  • Sample analysis assay optimization

  • SOP writing

  • Data recording and analysis

  • QC analysis

This position directly impacts preclinical outcomes including proof of concept, ED50, MED, clinical hold response and IND enabling studies

Qualifications

  • Bachelor’s degree in Molecular Biology, Biology, Life Sciences, or a related discipline with 5+ years of experience or a Master’s Degree with 3+ years of industry experience in molecular and cell biology techniques.

  • Ability to perform tissue extraction manually and on automated platforms

  • Proficient in qPCR & ddPCR

  • Proficient in RNA handling/storage and cDNA synthesis

  • Experienced using sterile technique and molecular assay handling

  • Proficient in QuantStudio Design and Analysis Software, QuantaSoft Software, and ImageJ

  • Experienced in quality control assessment

  • Experience in assay development/optimization

Preferred

  • Experience with Quality Assurance compliance and GLP-like procedures

  • Experience with SOP writing

  • Experience with Electronic Notebook Record Keeping

Working Conditions

This is a hands-on laboratory-based position that requires onsite work

Salary Range : $114,800 - $153,000 (NOTE: Final salary could be more or less, based on experience)

Benefits:

  • Medical, Dental and Vision Insurance

  • Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks

  • 401(k) match and annual company contribution

  • Company paid life insurance

  • Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

  • Long Term Incentive Plan for eligible positions

  • Referral bonus program

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.

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Category GT - Discovery Bioscience

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans

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