Job Information
Hologic Enzyme Development Scientist in San Diego, California
Enzyme Development Scientist
San Diego, CA, United States
As a leading innovator of women’s health, we at Hologic are empowering people to live healthier lives everywhere, every day.
R&D is the engine of our business here at Hologic, our R&D teams sit at the cutting edge of technology, our innovations are designed to achieve exceptional clinical results making it possible to detect, diagnose and treat illnesses and other health conditions earlier and with more certainty.
The R&D Assay Product Development team is looking for a candidate with considerable experience in protein biochemistry and assays and will function closely with a team of scientists to design processes for manufacture of proteins and related reagents. The candidate will join the Platform technology and Advanced Research group and will be responsible for developing wide-ranging knowledge in enzymes and associated protein/antibody systems applicable to Hologic’s Diagnostic Assays and Technology.
So, what will you do?
The Scientist 2, Enzyme Development is responsible for development and transfer of protein systems, including Enzymes and Antibodies. The position will work in collaboration with other departments and external stakeholders to develop all aspects of product development including specification setting, root cause investigations, test method development, transfer to manufacturing, on-market support, and other activities to ensure the robustness and performance of Hologic Diagnostic Assays.
Develop robust, scalable protein purification processes suitable for transfer to manufacturing
Purify proteins using column chromatography and filtration techniques
Perform functional and physical assays to assess protein purity and stability
Develop, generate, and verify buffer systems to support specific design requirements
Thoroughly and accurately document experiments as they are performed
Curate samples and generate process development reports
Help troubleshoot unexpected or challenging results within a team
Optimize and stress test process designs to ensure robust performance
Analyze, summarize, and present results to teams to drive design decisions and improvements
Provide guidance to other departments to ensure success of projects
May interact with upper management in communicating project status, issues, and resourcing
Feasibility, Assay design and transfer, formulation optimization and transfer, assay integration or V&V
Engages cross-functionally (Operations, Commercial, Regulatory, Quality, other R&D) to achieve Program goals
May be an independent contributor or supervise a team
We would like you to have:
Knowledge of FDA, IVDR, and ISO regulations related to in-vitro diagnostics preferred
Experience in Specification setting, Method development and transfer, and formal risk assessments
Working knowledge of enterprise tools, including electronic document & records management tools (SAP, Oracle, Agile), Microsoft office, JMP
Required Education and Experience:
BS with minimum 5 years, MS with minimum 3 years, or PhD with 0-3 years experience in Biochemistry, Molecular Biology, Microbiology, Chemistry, Chemical Engineering, Biomedical Engineering, or related field
Experience in analyzing proteins and nucleic acids using techniques such as SDS-PAGE, agarose gel electrophoresis, UV/Vis spectroscopy, fluorescence-based assays, or protein or nucleic acid quantitation
Familiarity with column chromatography techniques such as IMAC, affinity, ion exchange, hydrophobic interaction, or size exclusion chromatography
Familiarity with filtration techniques such as microfiltration, depth filtration, or tangential flow filtration
Experience with automated purification
Experience with buffer formulation for proteins and understanding of the chemical properties of salts, chelators, biological buffers, and reducing agents
Key additional requirements for us are:
Innovation: uses expertise and knowledge to provide high level perspective and innovative solutions to major projects
Judgement: combines expertise with experience to provide high level perspective and solutions to major projects
Strategic Thinking: manages priorities and secures support needed from other functions to complete the tasks
Planning: Identifies specific action steps, accountabilities, and timelines for completion of projects and provides accurate estimates for project resources and budget
Managing people: Manages or influences people in a constructive manner to achieve strategic and personal goals
Leadership: guides the technical aspects of projects and has courage to course correct even if it is difficult
Communication: distills complex technical information and delivers it to leadership so they can make effective decisions
Why join Hologic?
We are committed to making Hologic the destination for top talent. For you to succeed, we want to enable you with the tools and knowledge required and so we provide comprehensive training when you join as well as continued development and training throughout your career.
From a benefits perspective, you will have access to benefits such as medical and dental insurance, ESPP, 401(k) plan, vacation, sick leave and holidays, parental leave, wellness program and many more!
We can’t wait to hear from you!
The annual base salary range for this role is $93,000 to $145,500 and is bonus eligible. Final compensation packages will ultimately depend on factors including relevant experience, skillset, knowledge, geography, education, business needs and market demand.
Agency and Third Party Recruiter Notice:
Agencies that submit a resume to Hologic must have a current executed Hologic Agency Agreement executed by a member of the Human Resource Department. In addition Agencies may only submit candidates to positions for which they have been invited to do so by a Hologic Recruiter. All resumes must be sent to the Hologic Recruiter under these terms
or they will not be considered.
Hologic, Inc. is proud to be an Equal Opportunity Employer inclusive of disability and veterans.