MD Anderson Cancer Center Research Assistant II - Mouse Handling in Houston, Texas

Research Assistant II - Mouse Handling

Location: United States, Texas, Houston, Houston (TX Med Ctr) at

Research at

Cancer Medicine - Research 900080

Requisition #: 118314

The primary purpose of the Research Assistant II position is to conduct research in cancer biology of intestinal adenocarcinomas. In particular work will focus upon the exploration of the molecular characteristics of colorectal cancer and will focus upon characterization and treatment of PDXs. Mechanisms of treatment response and resistance. Research focus would also be in understanding the immune related aspects of colorectal cancer and to study the pathways involved in immune cells/tumor interaction, and immune checkpoint therapy. Projects will include the use of primary and xenograft tumors and cell lines cultures, genome wide molecular analyses, and animal work.

The department of GI Medical Oncology has a mission is to deliver the highest quality patient care by providing the most advanced medical therapies and opportunities to participate in clinical trials, with the goal of improving survival and quality of life. Research scientists are working to find better therapies, as well as more accurate diagnosis and screening procedures to detect GI cancers in their earliest stages.

The salary range is: min-$34,400, mid-$43,000 and max-$51,600.


Animal work:

• Manage mouse colony under minimal supervision.

• Perform survival surgeries for implantation of patient derived tumor fragments (PDX) and cell lines.

• Hands-on experience of drug dosing techniques (such as oral gavage, IP and SQ) are required.

• Measure tumor response via caliper and non-invasive imaging methods.

• Analyze the outcome of efficacy studies.

• Perform animal surgeries for collection of specimens for molecular characterization and ex vivo treatment. Previous experience with mouse tissue (blood, bone marrow, spleen, lymph nodes) collection are required.

• Extract immune cells from human tumor and mouse tissue (bone marrow, spleen, lymph nodes).

Record keeping:

• Maintain accurate, detailed records of mice colony (including growing PDX models). Ensure that data is entered in a timely manner.

• Ensure that the correct animal identification (ear tags) is placed on animals. Reporting any discrepancies to the supervisor is strongly advised.

• Ensure that all collected tissue samples are properly labeled and deposited to the storage. Ensure that data is entered in a timely manner.

Computer skills:

• Analyze and plot experimental data under minimal supervision. Advanced knowledge of Microsoft Excel and Adobe Photoshop is required.

Communication: Excellent verbal and written communication skills are required:

• Must be able to communicate results as well as any potential problems with experiments, in a clear and understandable manner to the supervisor and in lab meetings.

• Must be able to read articles and references and develop step-by-step written procedures to conduct experiments as well as communicate this information to the supervisor and other lab members.

• The ability to provide concise and accurate write ups of methods and results is desired.

Assistance with Lab personnel training:

• The capacity to assist with training of graduate students, fellows and post-doctoral trainees is desired.


• Must maintain a clean and orderly work place.

• Must have the ability and willingness to observe and comply with all institutional rules and OSHA regulations regarding biohazard and radiation safety.


Research laboratory environment, which may involve occasional exposure to hazardous equipment and materials.


Required: Bachelor's degree with major course works in one of the basic sciences.

Preferred: Bachelor's degree with major course works in veterinary (animal sciences).


Required: Two years experience in scientific or experimental research work. No experience required with preferred degree.

Preferred: Three years of experience in mice experimental work and mice colony maintenance.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.