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Lilly Advisor - DMPK in San Francisco, California

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At DICE Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, we design and develop innovative therapies in immunology. Our goal is to help patients with debilitating diseases. We aim to create a future where convenient oral medicines with biologic-like efficacy are available. We are developing oral alternatives to medicines currently limited to injectable forms.

Responsibilities:

We are seeking an Advisor, Drug Metabolism and Pharmacokinetics. This role requires expertise in designing, conducting, and interpreting in vitro ADME and preclinical PK and PK/PD studies. These skills are crucial for advancing DICE's small molecule Discovery & Development portfolio. The successful candidate will have strong laboratory, analytical, and project management skills, along with a solid foundation in drug disposition (ADME) science.

  • Conduct and/or oversee conduct of in vitro permeability, protein binding and other binding studies, metabolic stability, inhibition, phenotyping, transporters, and/or other in vitro ADME studies

  • Work with external CROs and vendors to establish, design, perform, and interpret results from in vitro ADME and/or PK studies

  • Contribute to optimizing workflow from compound submission to in vitro ADME and PK screening data readout

  • Evaluate new technologies, techniques, study designs, and/or equipment to enhance DMPK support of Discovery & Development programs

  • Understand application of ADME screening data within Research programs and apply such knowledge to enhance assays and/or the design and development of novel assays

  • Contribute to and influence the DMPK components in the screening funnel and criteria for compound selection and advancement in research programs. Identify, brainstorm, and resolve ADME/PK issues in research programs. Serve as the DMPK project representative in research programs

  • Help provide DMPK support to various departments such as Chemistry, Biology/Pharmacology, Toxicology, and Clinical pharmacology

  • Responsible for writing and/or reviewing DMPK reports

  • Contribute to nonclinical PK/ADME sections in regulatory documents (e.g., IB, IND, etc…)

Do you have experience with DMPK? Apply today to join the DICE Team!

Basic Requirements:

  • PhD in a relevant scientific field with 0-5+ years of industry experience

  • MS in a relevant scientific field with 10+ years of industry experience

Additional Skills/Preferences:

  • Experience in Drug Discovery/Development DMPK

  • Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills

  • Reasonable knowledge of PK and PK/PD studies to support characterization of small molecule therapeutics in Research programs

  • Familiarity with quantitative bioanalysis of plasma and other biological matrices is required. This skill supports pharmacokinetic, toxicokinetic, and in vitro ADME analyses of novel small molecule therapeutics

  • Familiarity with Excel, Prism, WinNonlin Phoenix (non-compartmental PK analysis) and other relevant ADME/DMPK software

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

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